Month: December 2012

With the New Year upon us, we thought we would use this week’s blog to revisit those studies we’ve particularly enjoyed reading and writing about in the past 12 months. In August, a landmark paper by Nookala et al., (2012) described the C-terminal domain structure of FLCN (PDB ID: 3V42). The authors showed FLCN had … Read more

As discussed in a previous blog post, the Rab family of small GTPases are known to be involved in membrane trafficking.  Two members of this family have now been associated with FLCN: Rab27B, using microarray studies (Hong et al., 2010; Klomp et al., 2010; Reiman et al., 2012), reviewed here, and Rab35, in an in … Read more

Dr Ilene Sussman became Executive Director of the VHL Family Alliance in 2011,  after leading the North American Thrombosis Forum, where she was responsible for developing new education and advocacy initiatives. Von Hippel-Lindau (VHL) disease is a multisystemic cancer syndrome caused by mutations in the VHL gene (Maher et al., 2011). Tumours can affect the … Read more

It is our pleasure to announce the Fifth BHD Symposium which will be hosted by Professor Stéphane Richard at the École du Louvre in Paris, France on 28-29th June 2013. As with previous Symposia, the aim is to promote a supportive international community for both BHD researchers and patients. In fact, Colledge & Solly (2012) … Read more