Month: March 2015

There are 338,000 new cases of kidney cancer per year worldwide, and the incidence has increased in recent years (Ferley et al., 2012). Although the majority of Renal Cell Carcinoma (RCC) cases are sporadic and affect those over 50 years old, 2-3% of cases are caused by inherited conditions such as BHD, VHL, HLRCC and … Read more

Under hypoxic conditions the activation of HIF transcription factors enables cells to alter their metabolism and avoid stress-induced apoptosis. Aberrant HIF activity in the inherited renal cancers BHD, VHL, HLRCC and TSC, is linked to the expression of growth and pro-angiogenic factors that are important in tumour growth. A new report from Doonachar et al., … Read more

A recent Findacure meeting focused on the importance and progression of drug repositioning in rare diseases. Dr Bruce Bloom, Dr Mike Briggs and Dr Farid Khan, discussed ongoing repositioning work, methods to identify new drugs and targets and the need for collaborations to drive new research and trials. Cures Within Reach are launching a new … Read more