FLCN may act as a molecular switch
Chromosome translocations involving the transcription factor TFE3, leading to its overexpression, cause roughly 15% of renal cell carcinomas in patients under 45 years of age (Kuroda et al., 2012). TFE3 is constitutively activated in FLCN-null cells (Hong et al., 2010), indicating that FLCN may regulate TFE3. While investigating the role of TFE3 in lysosome homeostasis … Read more