DBHD, the Drosophila homologue of FLCN, regulates mTor signalling
While increasing evidence suggests that mammalian FLCN acts in a number of signalling pathways such as mTOR signalling, Rho signalling, membrane trafficking and stem cell exit from pluripotency, FLCN’s precise function, and how it causes the symptoms seen in BHD is not known. The FLCN gene is highly conserved between species, with homologues in the … Read more