Your Resource for Birt-Hogg-Dubé Syndrome
Although the FLCN gene was identified in 2002 by Nickerson et al., studies trying to define the prevalence of BHD and the risks of developing the symptoms of BHD have proven difficult to determine, as discussed in this blog post. It would be of particular use to be able to accurately calculate the risk of … Read more
As has been noted in our blog review of 2012, a great deal of research in the BHD field has been published in the past year. Thus, it is only appropriate to reflect these changes in an updated version of our interactive signalling diagram. The FLCN-associated signalling diagram retains many of the features from previous versions, such as … Read more
Last week’s blog described a recent paper by Sano et al., which showed that FNIP2 is required for apoptosis in human cells. Additional studies have shown that FLCN and FNIP1 also function in apoptotic pathways, thus we have decided to review the current literature describing the role of FLCN and its associated proteins in apoptosis. … Read more
Previous studies in mouse cell lines have suggested that FLCN, FNIP2 and AMPK are involved in N-Nitroso-N-methylurea (MNU)-induced apoptosis (Lim et al., 2011 – described here). Using a human cell line, further work from the same group has now shown that FNIP2 appears to be stabilised by MNU treatment, and that this stability is modulated by … Read more